Of muscle modulation and the CFTR gate
نویسنده
چکیده
Modulating EC coupling In this issue, Berthier et al. identified an intriguing role for phosphatidylinositol 4, 5-bisphosphate (PIP2), a low abundance membrane phospholipid that modulates the activity of various membrane proteins, in regulating excitation–contraction coupling in skeletal muscle. Depolarization of the motor endplate initiates an action potential that propagates through the invaginations of the muscle plasma membrane that form the transverse tubule system. This triggers a conformational change in the dihydropyridine receptor, which acts as a voltage sensor to mechanically activate ryanodine receptors in the SR membrane, enabling Ca release from the SR to increase cytosolic Ca and thereby stimulate muscle contraction. Berthier et al. (2015) expressed voltage-sensing phosphoinositide phos phatases in mouse skeletal mus-
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عنوان ژورنال:
دوره 145 شماره
صفحات -
تاریخ انتشار 2015